Iron, Aging, and Neurodegeneration
نویسندگان
چکیده
منابع مشابه
Iron, Aging, and Neurodegeneration
Iron is a trace element of considerable interest to both chemistry and biology. In a biological context its chemistry is vital to the roles it performs. However, that same chemistry can contribute to a more deleterious role in a variety of diseases. The brain is a very sensitive organ due to the irreplaceable nature of neurons. In this regard regulation of brain iron chemistry is essential to m...
متن کاملAging and Neurodegeneration
Aging causes a slow deterioration of the brain function leading to cognitive decline, memory loss, movement disorders and finally to functional decline and death. With a rapidly increasing aging population, neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s become an important economic burden on the society. Unfortunately, there are no effective current therapies. Ther...
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The onset of age-related neurodegenerative diseases superimposed on a declining nervous system could enhance the motor and cognitive behavioral deficits that normally occur in senescence. It is likely that, in cases of severe deficits in memory or motor function, hospitalization and/or custodial care would be a likely outcome. This means that unless some way is found to reduce these age-related...
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متن کاملAbnormal iron homeostasis and neurodegeneration
Abnormal iron metabolism is observed in many neurodegenerative diseases, however, only two have shown dysregulation of brain iron homeostasis as the primary cause of neurodegeneration. Herein, we review one of these - hereditary ferritinopathy (HF) or neuroferritinopathy, which is an autosomal dominant, adult onset degenerative disease caused by mutations in the ferritin light chain (FTL) gene....
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ژورنال
عنوان ژورنال: Metals
سال: 2015
ISSN: 2075-4701
DOI: 10.3390/met5042070